Abstract
A series of small molecules with a piperidinyl core were synthesized and tested for binding affinity (IC50) at human Neuropeptide Y Y2 receptor. Various amide related analogs (ureas, reversed amides, and sulfonamides) were evaluated. Several potent and selective NPY Y2 antagonists were identified.
Copyright © 2013 Elsevier Ltd. All rights reserved.
MeSH terms
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Amides / chemical synthesis
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Amides / chemistry*
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Amides / metabolism
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Animals
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Drug Evaluation, Preclinical
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Humans
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Microsomes / metabolism
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Protein Binding
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Rats
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Receptors, Neuropeptide Y / antagonists & inhibitors*
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Receptors, Neuropeptide Y / metabolism
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Sulfonamides / chemical synthesis
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Sulfonamides / chemistry
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Sulfonamides / metabolism
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Urea / chemical synthesis
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Urea / chemistry
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Urea / metabolism
Substances
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Amides
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Receptors, Neuropeptide Y
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Sulfonamides
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neuropeptide Y2 receptor
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Urea